Resveratrol exhibits colon cancer prevention activity in animal models; it is purported to have this activity in humans and inhibit a key signaling pathway involved in colon cancer initiation, the Wnt pathway, in vitro. Design: A phase I pilot study in patients with colon cancer was performed to evaluate the effects of a low dose of plant-derived resveratrol formulation and resveratrol-containing freeze-dried grape powder (GP) on Wnt signaling in the colon. Eight patients were enrolled and normal colonic mucosa and colon cancer tissue were evaluated by Wnt pathway-specifi c microarray and quantitative real-time polymerase chain reaction (qRT-PCR) pre-and post-exposure to resveratrol/GP. Results: Based on the expression of a panel of Wnt target genes, resveratrol/GP did not inhibit the Wnt pathway in colon cancer but had signifi cant (p Ͻ 0.03) activity in inhibiting Wnt target gene expression in normal colonic mucosa. The greatest effect on Wnt target gene expression was seen following ingestion of 80 g of GP per day (p Ͻ 0.001). These results were confi rmed with qRT-PCR of cyclinD1 and axinII. The inhibitory effect of GP on Wnt signal throughput was confi rmed in vitro with a normal colonic mucosa-derived cell line. Conclusions: These data suggest that GP, which contains low dosages of resveratrol in combination with other bioactive components, can inhibit the Wnt pathway in vivo and that this effect is confi ned to the normal colonic mucosa. Further study of dietary supplementation with resveratrol-containing foods such as whole grapes or GP as a potential colon cancer preventive strategy is warranted. Trial registration: NCT00256334.

This article re-evaluates the significance attributed to Hecataeus' encounter with the Theban priests described by Herodotus (2.143) by setting it against the evidence of Late Period Egyptian representations of the past. In the first part a critique is offered of various approaches Classicists have taken to this episode and its impact on Greek historiography. Classicists have generally imagined this as an encounter in which the young, dynamic and creative Greeks construct an image of the static, ossified and incredibly old culture of the Egyptians, a move which reveals deeper assumptions in the scholarly discourse on Greeks and ‘other’ cultures in the Mediterranean world. But the civilization that Herodotus confronted in his long excursus on Egypt was not an abstract, eternal Egypt. Rather, it was the Egypt of his own day, at a specific historical moment – a culture with a particular understanding of its own long history. The second part presents evidence of lengthy Late Period priestly genealogies, and more general archaizing tendencies. Remarkable examples survive of the sort of visual genealogy which would have impressed upon the travelling Greek historians the long continuum of the Egyptian past. These include statues with genealogical inscriptions and relief sculptures representing generations of priests succeeding to their fathers' office. These priestly evocations of a present firmly anchored in the Egyptian past are part of a wider pattern of cultivating links with the historical past in the Late Period of Egyptian history. Thus, it is not simply the marvel of a massive expanse of time which Herodotus encountered in Egypt, but a mediated cultural awareness of that time. The third part of the essay argues that Herodotus used this long human past presented by the Egyptian priests in order to criticize genealogical and mythical representations of the past and develop the notion of an historical past. On the basis of this example, the article concludes by urging a reconsideration of the scholarly paradigm for imagining the encounter between Greeks and ‘others’ in ethnographic discourse in order to recognize the agency of the Egyptian priests, and other non-Greek ‘informants’.

In a series of studies, Ian Moyer explores the ancient history and modern historiography of relations between Egypt and Greece from the fifth century BCE to the early Roman empire. Beginning with Herodotus, he analyzes key encounters between Greeks and Egyptian priests, the bearers of Egypt's ancient traditions. Four moments unfold as rich micro-histories of cross-cultural interaction: Herodotus' interviews with priests at Thebes; Manetho's composition of an Egyptian history in Greek; the struggles of Egyptian priests on Delos; and a Greek physician's quest for magic in Egypt. In writing these histories, the author moves beyond Orientalizing representations of the Other and colonial metanarratives of the civilizing process to reveal interactions between Greeks and Egyptians as transactional processes in which the traditions, discourses and pragmatic interests of both sides shaped the outcome. The result is a dialogical history of cultural and intellectual exchanges between the great civilizations of Greece and Egypt.

PGM XII.270-350, a text prescribing rituals for the creation and use of a magical ring, provides a particularly useful example through which to explore the phenomenon of miniaturized ritual in the magical papyri of late Graeco-Roman Egypt (as elucidated by Smith 1995). The ritual for creating and consecrating the ring's gemstone makes it clear that the stone is considered a miniature cult statue. The subsequent "Ouphor" invocation to be performed whenever the ring is used corresponds in name and function to the Egyptian wp. t-r or Opening the Mouth ritual as used in daily temple liturgy. The nature of these ritual miniatures reveals the sophisticated discursive and conceptual level at which the traditional forms of temple ritual were adapted and redeployed for use in other contexts by members of the Egyptian priestly class in late antiquity.

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