Background: Giant cell tumor is locally aggressive benign tumor that occur more common in distal femur, proximal tibia, and distal radius, and has tendency for recurrence and has capability for metastatize. Giant cell tumor in foot ankle are rare, and comprise less than four percent of giant cell tumor of the bone.Case Report: A 33 years old man presented with complains of pain and swelling in right ankle since 6 months ago with no history of trauma. Physical examination revealed increasing swelling over the distal-posteromedial aspect of lower leg and limitation ankle movements due to pain. Routine blood investigations showed slight increase of alkaline phosphatase. X-ray and Magnetic Resonance Imaging showed the lesion with morphology suggestive of giant cell tumor. Histopathology examination showed multinucleated giant cells and spindle shaped of mononuclear cells suggestive of giant cell tumor. The patient was treated with en-bloc-excision followed with distal tibial reconstruction using reverse intramedullary tibial nail combined with T-plate (tibio-talar arthodesis).Discussion: The main treatment of giant cell tumor of the bone is surgical removal to achieve tumor-free by eradication of the tumor, with various surgical techniques for reconstructing the cavity left. In this case we performed distal tibial reconstruction using reverse intramedullary tibial nail combined with T-plate.Conclusion: The patient at 12-month follow up is doing well, walking comfortably without any pain, has no limitation in range of motion with no signs of recurrence and good MSTS score (90).

Abstract. Prasetyo AA, Sariyatun R, Prasetyo AD, Yudistiro I, Sidhajati RA. 2014. G1957C variation in Core Promoter and Precore/Core regions of Hepatitis B virus isolated from men who have sex with men (MSM) in Surakarta, Central Java, Indonesia. Nusantara Bioscience 6: 107-110. Little is known about HBV isolates in Indonesian men who have sex with men (MSM) community. Thus, this study was aimed to analyze the genetic profile of HBV isolated from MSM in Indonesia, particularly in Surakarta, Central Java. A total of 205 blood samples were examined by polymerase chain reaction (PCR) targeting the partial Core Promoter (CP) and Precore/Core (preC/C) regions. Three samples were found positive by PCR. The amplicons were sequenced and subjected to molecular analysis. The genetic profile of all HBV isolated in Indonesia (n= 122) was also included for molecular analysis. All HBV isolated from the MSM were genotype B3. G1957C (C195S) was found in all HBV isolated from the MSM community and subject with sex with man history. Several disease-related mutations were observed among HBV sequences from Indonesia, including T1753C, A1762T, G1764A, A1846T, and G1896A which existed in 7.2% (9/125), 17.6% (22/125), 19.2% (24/125), 16.8% (21/125), and 24.8% (31/125) sequences, respectively; however, none were present in HBV isolated from the MSM. In conclusion, various mutations, including those related to disease, were found in Indonesian HBV isolates. G1957C variation was unique in the HBV isolated from the MSM.

Introduction: Coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus (SARS Cov-2) has made a huge impact on global health service including in orthopaedic surgical service. Knee surgery (including arthroscopy) is one of the emerging surgical services in Indonesia. As the pandemic goes on, some of the patients prefer to postpone or cancel the surgery planning. We tried to evaluate the epidemiology of knee arthroscopy procedure during Covid-19 pandemic at our institution. Material and methods: Retrospective data collection was performed on all patients who received knee arthroscopy procedure at Prof dr. R. Soeharso Orthopaedic Hospital, Surakarta, Indonesia during the year 2020. The study evaluated the demographic data, the indication of surgery, and trends of the number of surgeries according to period time. This study also compared the data of knee arthroscopy procedures performed during the corresponding period before the pandemic in Indonesia (January to December 2019). Results: There was a total of 88 knee arthroscopy surgery performed during the period January to December 2020. There was a decrease in the number of knee arthroscopy during April and May 2020.  The decreasing number of surgeries also occurred in November 2020 which was later followed by the increasing number of surgeries in December 2020. Among all patient received knee arthroscopy during 2020, none have post-operative complication or infection due to SARS Cov-2. Conclusion: There was some difference in the epidemiology of knee arthroscopy during the COVID-19 pandemic compared to the non-pandemic era. Comprehensive preoperative screening is needed before resume elective surgical service.