INTRODUCTION:When severe cases of SARS-CoV-2 (COVID19) require admission to the ICU, the presentation will often fulfill criteria for Acute Respiratory Distress Syndrome (ARDS). Some studies have attempted to define the differences between COVID19 related ARDS and non-COVID19 ARDS. However, there is little data on differences in use of vascular access. While central and arterial lines are essential for ICU care, there are risks associated with their use, notably infection, bleeding, and thrombosis. This study attempts to explore if there were differences in line usage rates and complications between patients with COVID19 ARDS and non-COVID19 ARDS. METHODS: This analysis was a retrospective cohort study.A cohort of patients with COVID19 ARDS (n = 86) was compared to a cohort of patients with non-COVID19 ARDS (n = 47). We compared baseline characteristics, total number and placement rate of lines (arterial lines, central venous catheters, and dialysis catheters) and incidence of line related complications (bleed, thrombosis, or infection).