Giant cell tumor (GCT) is a bone tumor that is encountered frequently and can have both benign and aggressive characteristics. It is commonly found in individuals between the ages of 20 and 45, with a slightly higher incidence in females. A 22-year-old female presented with a progressively increasing painful and tender lump in the distal forearm, along with restricted wrist movements and inability to use her right hand. The patient's medical history was complicated by the ongoing Syrian conflict, which limited her access to medical care and resources. Physical examination showed a large lump in the distal radius and severely restricted pronation and supination, additionally, Plain radiographs and computerized tomography (CT) were suggestive of an aggressive giant cell tumor (GCT) of the proximal humerus, which was confirmed on histopathological examination. After appropriate investigation, we decided to proceed with En bloc resecting and reconstructing the resultant defect with a proximal non-vascularized fibula graft. Despite the challenges posed by the Syrian conflict, our surgical intervention successfully restored the patient's arm function and provided her with a positive outcome. This case highlights the importance of adapting to difficult circumstances in order to provide necessary medical care to patients affected by conflict and other adverse situations.