Normal human subject can have baseline auto-antibodies and auto-reactive immune cells constituting the normal physiological autoimmune state. On, post- sars-cov-2 infection and post-vaccination periods either the virus built in spike protein in case of post-infection . Or the peptide expressed from the spike protein sequence within the human COVID -19 mRNA vaccines have an auto-reacting epitopes within the human vaccinee cells. Both of the virus spike protein and vaccinee cells are bearing either pan-sharing molecular mimicking or mono-specific molecular mimicking epitopes that initiate on continual exposure to the immune system cells mediating an autoimmune responses. Such responses may cause an immune conversion of the antibody and /or auto-reactive immune cells levels from the baseline limits to the clinically indicative levels of auto-antibody and/or auto-reacting cells. The immune conversion state may pose to an autoimmune tissue injuries as single or multiple organs defects expressing the patho-biologic features of autoimmune long COVID-19.This mechanistic view to the long Covid-19 is parallel with inclusion of long COVID-19 on the list of autoimmune registry 2021.Some workers holds the believe that autoimmune long COVID-19 is an auto-antibody mediated condition .Other workers are of the opinion that both auto-antibody and auto-reacting immune cells may be involved in, Though there is still existing some debate .A literature show case analysis of neural autoimmune long COVID-19 was tempted .A laboratory animal model for Post-infection-Post-vaccination autoimmune long COVID-19 was suggested .Both of these disease entities are being over-lapping.

Abstract:Oral mucosal tolerance a phenomenon among others in the common mucosal immune system. The mechanisms behind which are multiple. Three main opinions are being raised up .First ,tolerant cells emerged within the gut mucosa and migrates to oral mucosa suppressing immune function ,the second holds that tolerant cells evolved with in the sublingual salivary glands and functions insitue and the third ,however ,considered tolerance as an active immune processes marked with hypersensitivity and antibody formation.

At most BCG vaccination in childhood is being finalized with scar formation. Absence of BCG scar formation few days post-vaccination can be a state of anergy. Though, gradual scar fade up may demonstrate a case of waning immunity. The present work was performed onto three groups of healthy children. Scar bearing BCG vaccinee child, non-scar bearing BCG vaccinee child and non-vaccinated child as controls. Age, scar size and macrophage inhibitory factor MIF cytokines were determined. A fraction of scar bearing BCG vaccinee were showing lower MIF concentration than normal controls. A state of waning cytokine responses in spite of the presence of scar. Likewise, a fraction of non-scar bearing BCG vaccinee were showing MIF concentrations lower than that of normal healthy controls ,a state of waning cytokine responses that parallels the waning of gross manifestation of the scar reactions. These findings point out the condition of heterogeneity or divergency of the immune response to BCG vaccines in childhood. MIF cytokine herd response were showing low moderate, and high responders in vaccinated children. The MIF cytokine herd response plots were of Gaussian distribution plots.

Humans lives in modern society are subjected to an array of factors that impacts the cellularity and  functionality of their immune systems. These  IMSH factors  were ensemble as; Global changes, liberal spread of mental influencing drugs, war warfare ,terrorism  ,environmental mutagens and carcinogens  as well as environmental allergens .So they are being at risk for both enhancing or dampening effects on their immune systems. Workers have been documenting four main categories of targeted  human immune system  living at risk  of modern society .The   IMSH   categories are; intravenous   drug users, intensive care patients, tumor patients ,  war warfare and terrorism. The intravenous drug users have shown increase in their humoral B cell immune responses  through the elevation of B cell counts and activities and increase in activation markers of T cell subsets. Intensive care patients were mainly  showing  functionality of cellular immunity like that of ageing immune cells. Tumor patients, however, were found expressing diversity and  compositional heterogeneity of  immune cell type reaching  33 subsets and marked functional alterations. Tumor microenvironment  have shown at least six  dominant  pan-cancer-classes of dominant  immune cells as compared to normal human subjects immune cellularity. Biological warfare and bioterrorism insults  were being accompanied  by emergence and re-emergence of unfamiliar  agent pathogenicity ,seasonality  and marked host susceptibility to the terrorism  agent necessary need for individual therapy  and management ,as well as for pre and post exposure  mass vaccination .Each IMSH category have expressed shared and distinctive features. The unified functional insight to the immune systems of human living in modern society is that formed cellular elements of these  immune systems behave to different insults in different ways and different elements reacts differently to the same insult.

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