The texture of the cryoglobulin was gelatinous 49:60(81.7 %) and flocculent 8: 60 (13.3 %). The mean of cryocrit percent among typhoid patients was 6.1 % while among control was 0.2 Cryoglobulin response was associated with RF in 28:57 (49.12 %) among typhoid patients sera and nil among controls. The immunofixation studies using radial immunodiffusion in gel have shown that type of cryoglobulin response was of mixed type IgG-IgM-IgA. The RF associated cryoglobulinemia have shown higher IgG concentration than non RF associated cryoglobulin. The Ig classes have shown individual variations .S.typhi O agglutinins were 46:57 (80.7 %) in typhoid. Thus , type IIIsecondary mixed IgG-IgM-IgA cryoglobulinemia associated with typhoid patients sera with S.typhi O specific cold agglutinins as well .

No abstract

No abstract

The oral microbiome is formed and functioned in balanced state during health and in an unbalanced state in the disease conditions. Microbiome in the oral compartment combats the weapons of the invading microbial pathogens. Now, there are a specific microbiome signature in each of the cases of health and disease. Oral microbiome expressed; probiotic, antigenic competition and immunomodulatory effects locally in the oral compartment .In the immunologic sense, oral microbiome is constituting an element that is able to interact in a bidirectional fashion with the components of the oral immune compartment with the net result of homiostasis, immune response ,tolerance, anergy and hypersensitivity and/or immune mediated diseases. Thus it has played an important roles in oral immune mechanisms.

No abstract