Objective: In this study we aimed to compare the effects of submucosal cauterization of the inferior turbinate with or without inferior partial turbinectomy. Materials and methods: In this prospective cohort study, 60 patients with inferior turbinate hypertrophy were randomized and divided into two groups. The first one was submitted to submucosal cauterization associated with partial turbinectomy, and the second one only submucous cauterization. Five items were assessed to compare both methods: pain, nasal bleeding, scarring, crustation and nasal air way patency. Follow-up was performed on days 1, 14, 30 and 3 months later. Results: In both groups crusting formation was similar. Reactionary hemorrhage was more common in turbinectomy group. Scarring showed better results in the turbinectomy group in the first month postoperative, airway patency showed good results in 80% of the patients with turbinectomy. Conclusion: Submucosal cauterization with inferior partial turbinectomy has yielded better nasal patency when compared to submucosal electrocautery ablation alone.
Objectives/Hypothesis
Laryngomalacia is the most common cause of stridor in infants. The exact pathophysiology is still not well understood. Our objective was to investigate whether laryngomalacia is an inflammatory disease, focusing on the possible role of vitamin D.
Study Design
Case‐control study.
Methods
Sixty Egyptian infants and 60 mothers were included in this study. They were divided into four equal groups (n = 30 for each): infants with laryngomalacia (LM‐infants), control infants (C‐infants), mothers of the infants with laryngomalacia (LM‐mothers), and mothers of the control infants (C‐mothers). Laryngoscopy was performed and serum 25‐hydroxyvitamin D (25[OH]‐vitamin‐D) and interleukin 6 (IL‐6) were estimated.
Results
Significant increase of serum IL‐6 associated with a significant decrease in serum 25(OH)‐vitamin D was observed in the LM‐infants compared to the C‐infants (P < .001 for both). LM‐mothers had significantly lower 25(OH)‐vitamin D status compared to C‐mothers (P < .001).
Conclusions
Deficiency of 25(OH)‐vitamin D in LM‐infants may result in dysregulation of the immune responses with elevation of a proinflammatory cytokine (IL‐6). Laryngomalacia could be an inflammatory disease due to 25(OH)‐vitamin D deficiency as evidenced by the high level of IL‐6. This finding may open the door to the appropriate prevention, diagnosis, and treatment, especially for moderate to severe laryngomalacia.
Level of Evidence
3b Laryngoscope, 130:448–453, 2020
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