Different simulation methods can be used to model the response of structures to the effects of blast loading. While some simulation methods are based on empirical blast loading principles, other methods use a fluid structure interaction algorithm to predict post-explosion shock waves and their physical effects. In this study, CONWEP, SPH, ALE, and coupled MM-ALE with LBE numerical methods were compared against each other according to results from an experimental study. Each method was compared with the test results in terms of solution time, convergence, and the use for different explosive types and environments. According to this comparison, it was concluded that empirical methods can be used for more limited environmental conditions and blast types, ALE numerical methods can give very sensitive results even in different solution sets but the solution time is long. Meanwhile in SPH method, the interaction of the air and blast shock cannot be fully modelled. According to the results of the study, the hybrid method is consistent with the test results in terms of peak pressure with a deviation of 7.44% at P1 and 2.29% at P2 under spherical free air blast loading conditions. However, since the effects of reflected pressure cannot be modelled exactly in the hybrid method, the ALE method should be preferred in cases with more complex geometries.