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<p>Ce travail de recherche a lieu dans un contexte d’innovation curriculaire, marquée par une diminution drastique des effectifs dans les séries scientifiques maliennes comme partout ailleurs. Nous avons donc réalisé une enquête auprès de 600 élèves de Seconde CG (14-15 ans) et 100 élèves-maîtres de 2e année IFM, afin d’identifier leurs rapports aux Sciences physiques et chimiques (SPC), ainsi qu’auprès de 50 enseignants du secondaire sur leur mode d’appropriation de l’APC. Les résultats ont mis en évidence une relation entre l’attitude négative et les sujets d’évaluation de la part de 52% et 85%, respectivement des élèves et élèves-maîtres enquêtés. Ces pourcentages défavorables envers les SPC, qui sont les plus élevés parmi nos résultats, peuvent être minimisés par l’application correcte de l’Approche Par Compétence (APC), non encore effective par manque de formation des enseignants ; car 56,5% des élèves de seconde CG sont désireux de poursuivre en 1re Science. </p><p> </p><p>This research takes place in a context of curricular innovation, marked by a drastic decrease in enrollments in Malian science programs as elsewhere. We conducted a survey of 600 Seconde CG students (14-15 years old) and 100 student-teachers in their 2nd year of IFM to identify their relationships with Physical and Chemical Sciences (PCS), as well as 50 secondary school teachers on their mode of appropriation of the APC. The results highlighted a relationship between negative attitude and evaluation topics among 52% and 85%, respectively, of the surveyed students and student-teachers. These unfavorable percentages towards PCS, which are the highest among our results, can be minimized by the correct application of the Competency-based Approach (CA), which is not yet effective due to lack of teacher training; because 56.5% of high school 1st year students are willing to pursue in 2nd year Sciences.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0005/a.php" alt="Hit counter" /></p>

Beta-2-microglobulin (B2M) is a low molecular weight polypeptide (11,800 Da) that exists in a free form and a form bound to cell membranes (light chains of HLA class I molecules). Their dosage is used in the exploration and monitoring of renal function in haemodialysis patients, hence the interest of this study, the objective of which is to study the different players involved in the increase of beta-2-microglobulin. Materials and Methods: This was a prospective and descriptive study from January 1 st , 2017 to August 31, 2017 (08 months). All patients with chronic hemodialysis for 3 years or more were included. We analyzed sociodemographic, clinical and paraclinical data. Results: We collected 50 patients. The mean age was 50 ± 4.6 years with extremes of 30 and 82 years. The female sex predominated (52%). Chronic end-stage renal failure was hypertensive (86%), diabetic (4%). All patients benefited from intermittent hemodialysis for 8 hours per week using a low permeability membrane (cuprophane). The average duration of hemodialysis was 68 ± 6.4 months with extremes of 36 and 204 months. Twenty percent (20%) and four percent (4%) of chronic dialysis patients had joint pain and sensory deficit. Phalen's sign was positive in 2% (1 case), Tinel's sign in 2%

Context: The coexistence in the same patient of a mixed connectivitis or Sharp's syndrome is a rare eventuality. Objective: To underline the presence of this mixed connectivitis in our practice, whose prevalence remains unknown, particularly in Africa and more precisely in Mali. Case Presentations: We report two cases of Sharp's syndrome in a 48-year-old man and a 40-year-old woman with impaired renal function. The picture achieved associated massive proteinuria, hypoalbuminemia, moderate renal failure and edematous syndrome in men. In women, the picture was associated with accelerated to malignant hypertension and severe renal failure. There were no osteoarticular manifestations and the diagnosis of Sharp's syndrome was based on the presence of high levels of antibodies to U1RNP. Therapeutic management has been that of predominantly associated connective tissue disease (systemic lupus erythematosus). Conclusion: Mixed connectivitis or Sharp's syndrome is increasingly recognized as a separate entity thanks to advances in molecular biology. Its prevalence is low in sub-Saharan African countries with renal disease that manifests itself as proteinuria or nephrotic syndrome associated with microscopic hematuria, renal failure, and hypertension. This renal impairment is more likely to occur in severe forms of the disease.

Introduction: Erectile Dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for sexual intercourse. The frequency of erectile dysfunction in patients with kidney failure is estimated at 50% to 70%. The objective of this work was to determine the frequency of sexual dysfunction in chronic hemodialysis patients, to evaluate the psycho-social impact and to describe hormonal disturbances. Patients and Methods: This was a descriptive prospective study carried out from 3 April to 31 August 2017 in the nephrology and haemodialysis department of the Point G University Hospital. She has been interested in men over the age of 18 who have been on chronic hemodialysis for more than a year. Sexual dysfunction was assessed using the questionnaire: International Index of Erectile Function (IIEF-5). Results: Sixty-five patients were included. Forty-six (70.8%) had severe (30.8%), moderate (13.8%) and mild (26.2%) ED. 56.9% of patients had libido disorders, with decreased sexual desire (38.5%); absent sexual desire (18.5%). Sexual desire was normal in 43.1% of patients. Sexual activity was absent in 20 patients (30.8%). Sexual rigidity was reduced in 28 patients (43.1%) and normal in 24 patients (36.9%). The mean age of our patients was 42.55 years with a median age of 40 years and extremes of 23 and 74 years. Eighty percent were married. Nine patients (13.8%) were using sildenafilbased medications. Antihypertensives were prescribed in 93.9% and erythropoietin in 30.8% of patients. The main impact groups were anxiety (53.8%