Background: Low Birth Weight (LBW) in infants is still a problem in the health sector, especially perinatal health. The prevalence of low birth weight babies (BBLR) is estimated to be 15% of all births in the world with a 3.3%-38% limit and is more common in developing countries or low socioeconomic countries. Frequent complications of LBW such as hypothermia, respiratory disorders, gastrointestinal disorders, immunological disorders, liver immaturity, renal immunity and bleeding. In LBW, there can be a lack of surfactant and not yet perfect growth and lung development so that difficulties start breathing which result to occur Neonatal Asphyxia. The purpose of this study was to determine the relationship of degree of LBW with the degree of Neonatal Asphyxia. Methods: The type of research used is observational analytic with cross sectional study design. In this study, sampling was performed at LBW at Wangaya Hospital April 2016-April 2017 period in NICU and Perinatology room until the number of research samples fulfilling the inclusion and exclusion criteria with total sample of 87 samples. The sample is obtained by consecutive sampling method, then collecting the necessary data. The data obtained were analyzed analytically, then presented in tabulation data and described using tables and narration. Result: There was a significant correlation between degree of BBLR and degree of Asphyxia Neonatarum (p = 0,03), BBLR was risk factor to degree of asphyxia with prevalence prevalence (RP) = 2.08 (95% CI = 1.08-1, 30). Conclusion: There was a significant correlation between degree of LBW and degree of Neonatal Asphyxia.