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Plasmocidr6-methoxy-8-(3-diethylaminopropy1amino)quinolrine] was one of a large number of 8-aminoquinoline derivatives examined during the recent wartime search for more effective antimalarial drugs (Wiselogle, '46). As mas the general practice in this search, detailed studies of the reactions of various lower animals to the above compound were made preliminary t o a projected trial in liuman mal t~r i a .~ These investigations, which iiduded both acute and subacute experiments, revealed rather striking differences in the effects of Plasmocid on different experimental animals (Wiselogle, '46). In rhesus and cynomolgus monkeys, fatal intoxication produced a complex group of neurological symptoms including extreme hyperesthesia, nystagmus, loss of pupil1,ary reflexes. loss of equilibrium, and incoordination of lPart of the work described in this report was carried out under a contract recommended by the Committee on Medical Research beween the Office of Scientific Rmearch and Development and The Christ Hospital Institute of Medical Research.aThe compound was designated as SN 3115 in the records of the Survey of Antiinalarial Drugs (Wiselogle, '46). It was described originally by Fornrau, Tr6fouB1, Bovet and Benoit ('31) and has been designated since as F 7'10, Rliodoquine, Plasmocide, Plasmozid, and Plmmocid.S A s a result of the findings in experimental animals, the activity of Plasmocid against human nialaria was not studied during the OSRD program. 337

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