Capnography is commonly used to monitor patient's ventilatory status. While sidestream capnography has been shown to provide a reliable assessment of end-tidal CO 2 (ETCO 2 ), its accuracy is commonly validated using commercial kits composed of a capnography monitor and its matching disposable nasal cannula sampling lines.The purpose of this study was to assess the compatibility and accuracy of cross-paired capnography sampling lines with a single portable bedside capnography monitor. A series of 4 bench tests were performed to evaluate the tensile strength, rise time, ETCO 2 accuracy as a function of respiratory rate, and ETCO 2 accuracy in the presence of supplemental O 2 . Each bench test was performed using specialized, validated equipment to allow for a full evaluation of sampling line performance.The 4 bench tests successfully differentiated between sampling lines from different commercial sources and suggested that due to increased rise time and decreased ETCO 2 accuracy, not all nasal cannula sampling lines provide reliable clinical data when cross-paired with a commercial capnography monitor. Care should be taken to ensure that any cross-pairing of capnography monitors and disposable sampling lines is fully validated for use across respiratory rates and supplemental O 2 flow rates commonly encountered in clinical settings.

Capnography is commonly used to monitor patient's ventilatory status. While sidestream capnography has been shown to provide a reliable assessment of end-tidal CO 2 (ETCO 2), its accuracy is commonly validated using commercial kits composed of a capnography monitor and its matching disposable nasal cannula sampling lines. The purpose of this study was to assess the compatibility and accuracy of cross-paired capnography sampling lines with a single portable bedside capnography monitor. A series of 4 bench tests were performed to evaluate the tensile strength, rise time, ETCO 2 accuracy as a function of respiratory rate, and ETCO 2 accuracy in the presence of supplemental O 2. Each bench test was performed using specialized, validated equipment to allow for a full evaluation of sampling line performance. The 4 bench tests successfully differentiated between sampling lines from different commercial sources and suggested that due to increased rise time and decreased ETCO 2 accuracy, not all nasal cannula sampling lines provide reliable clinical data when cross-paired with a commercial capnography monitor. Care should be taken to ensure that any cross-pairing of capnography monitors and disposable sampling lines is fully validated for use across respiratory rates and supplemental O 2 flow rates commonly encountered in clinical settings.