No abstract

This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections.Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and nonpharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. . Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 -346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 -99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 -5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.