Primigravida women are those who conceive for the first time and are at high risk group for complications during childbirth Objective: To compare the effectiveness of phloroglucinol i/v and drotaverine hydrochloride by measurement of the 1st stage of labor in primigravidae. Methods: This randomized controlled trial was held in the Obstetrics and Gynecology Department of Allama Iqbal Memorial Teaching Hospital Sialkot and The Indus hospital QF-NST Campus Lahore for six-months duration from July to December 2021. Several factors were used to determine the inclusion of primigravida females, including age range of 20- 35 years, 38-42 weeks of gestational age at LMP with single pregnancy, Uterine contractions up to 3 cm if they occur at 3-4, 10 minutes before both drugs are given, ROM, no signs of fetal and maternal distress, patient in the first stage of labour. All of the cases were divided into two groups: A and B. Group 'A' received phloroglucinol 40mg (4ml) i/v at 4 cm dilation, and the dosage was repetitive at 8 cm dilation. At 4cm dilation, Group 'B' received drotaverine 40mg i/v. The essential signs including uterine contractions and fetal heart rate were monitored every half an hour. Results: 80 patients were included, with 56.3% of cases in Group-A group B has 43.7% cases being between the ages of 20-35 years. There was a significant improvement in the first stage of active labour ’mean duration in Groups A and B is 160.21±4.29 minutes and 203.77±8.21 minutes, respectively. Conclusion: The mean active length of the 1st stage of labour in the group of phloroglucinol was substantially shorter than in the drotaverine group