The interaction of calixarenes and amines in CH3CN solution is postulated to involve a two-step process, viz., proton transfer from the calixarene to the amine to form the amine cation and the calixarene anion followed by association of the ions to form a complex. The overall association complex for p-allylcalix[4]arene and ZerZ-butylamine, as a typical example, is about 106, the larger part of this arising from the proton transfer, as measured from UV spectral observations, and the smaller part arising from the association of the ions, as measured from *H NMR observations. A 2D NOE spectrum of this complex indicates that the methyl groups of the amine and the allyl groups of the calixarene are proximate, in agreement with an emfo-calix structure for the complex.
Obesity is a major health issue in developed as well as developing countries. While obesity is associated with relatively good health status in some individuals, it may become a health issue for others. Obesity in the context of inflammation has been studied extensively. However, whether obesity in its various forms has the same adverse effects is a matter of debate and requires further research. During its natural history, metabolically healthy obesity (MHO) converts into metabolically unhealthy obesity (MUHO). What causes this transition to occur and what is the role of obesity-related mediators of inflammation during this transition is discussed in this paper.
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