This paper presents a comprehensive pedagogical research related to mathematics instruction at the tertiary, university-level. Developed educational materials in electronic format, using the Matlab software package are integrated into instruction. The impact of using ICT on the essential knowledge related to the multivariate calculus, intensive use of 3D static and dynamic visualization tools has been statistically investigated. Some of students (experimental group) involved in the research study have individually created Matlab programs. Part of the research study is focused on the potential impacts of programming skills on learning mathematical concepts.