Use of patient-selected treatment partners was associated with improved drug pickup adherence and initial virologic success but had no durable effect on attaining undetectable viral load.
Background-Presence of Human Leukocyte Antigen (HLA) B*57:01 allele predicts hypersensitivity reaction (HSR) to Abacavir (ABC), a nucleoside reverse transcriptase inhibitor used for HIV treatment. However, prevalence of this allele among Nigerians with HIV is yet to be established. We aimed to determine the prevalence of HLA B*57:01 allele among Nigerians with HIV infection.Methods-We conducted a multicenter cross-sectional epidemiologic survey. Between April 2016 and April 2017, patients were enrolled across 5 HIV treatment facilities in Nigeria. Participants' demographic information and history of ABC exposure were obtained, and venous blood obtained for HLA typing.Results-One thousand five hundred and four (1,504) adults were enrolled, with a mean age of 44.6 ± 10.7 years, 1,078 (71.7%) were female. 1,463 (97.3%) were on antiretroviral therapy. ABC use was reported by 12 (0.8%) participants and none reported HSR. Of 1,500 blood samples that
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