Márton I, Kiss C, Balla G, Szabó T, Karmazsin L. Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. Alpha‐ 1‐antitrypsin, alpha‐2‐macroglobulin, C‐reactive protein, haptoglobin and complement C3 component concentrations and oxidase activity of ceruloplasmin were studied in sera of 36 patients with chronic periapical granuloma before and after surgical treatment. Mean serum concentrations of the investigated proteins were slightly elevated at diagnosis, with the exception of haptoglobin. Alpha‐1‐antitrypsin and ceruloplasmin levels decreased significantly 7 days after apicectomy, the 4 other proteins were unchanged at this sampling. Each investigated protein decreased significantly 3 months after apicectomy. This is the first longitudinal study of “acute‐phase proteins” in chronic periapical granuloma.