Dry eye disease (DED) is a common eye condition worldwide and a primary reason for visits to the ophthalmologist. DED diagnosis is performed through a combination of tests, some of which are unfortunately invasive, non‐reproducible and lack accuracy. The following review describes methods that diagnose and measure the extent of eye dryness, enabling clinicians to quantify its severity. Our aim with this paper is to review classical methods as well as those that incorporate automation. For only four ways of quantifying DED, we take a deeper look into what main elements can benefit from automation and the different ways studies have incorporated it. Like numerous medical fields, Artificial Intelligence (AI) appears to be the path towards quality DED diagnosis. This review categorises diagnostic methods into the following: classical, semi‐automated and promising AI‐based automated methods.

With a prevalence of 5 to 50%, Dry Eye Disease (DED) is one of the leading reasons for ophthalmologist consultations. The diagnosis and quantification of DED usually rely on ocular surface analysis through slit-lamp examinations. However, evaluations are subjective and non-reproducible. To improve the diagnosis, we propose to 1) track the ocular surface in 3-D using video recordings acquired during examinations, and 2) grade the severity using registered frames. Our registration method uses unsupervised image-to-depth learning. These methods learn depth from lights and shadows and estimate pose based on depth maps. However, DED examinations undergo unresolved challenges including a moving light source, transparent ocular tissues, etc. To overcome these and estimate the ego-motion, we implement joint CNN architectures with multiple losses incorporating prior known information, namely the shape of the eye, through semantic segmentation as well as sphere fitting. The achieved tracking errors outperform the state-of-the-art, with a mean Euclidean distance as low as 0.48% of the image width on our test set. This registration improves the DED severity classification by a 0.20 AUC difference. The proposed approach is the first to address DED diagnosis with supervision from monocular videos.