Use of boron trifluoride etherate and trichloromethylsilane in the presence of zinc-copper couple effects a crossed imino pinacol coupling reaction to give 1,2-diamines in good yields with high diastereoselectivities.

Polyphenylalkane derivativesPolyphenylalkane derivatives Q 0720 Highly Chemoselective Crossed Imino Pinacol Coupling Reaction Using the Synergetic Effect of Boron Trifluoride Etherate and Trichloromethylsilane. -The title conditions permit a fairly efficient cross-coupling of imines (I)/(II) and (VII)/(VIII) to give 1,2-diamines (III) and (IX) in high diastereoselectivities. In all cases, lower amounts of type (V) and (VI) are also obtained. -(SHIMIZU*, M.; SUZUKI, I.; MAKINO, H.; Synlett 2003, 11, 1635-1638; Dep. Chem. Mater., Fac. Eng., Mie Univ., Tsu, Mie 514, Japan; Eng.) -Mais 02-115

No abstract