In previous research, a new nonthermal plasma hybrid reactor was developed for removing SO2 from flue gas. The high efficiency and cost performance were proven through experiments. However, the research on simultaneously removing SO2 and NO x has not yet been reported. The objective of this work is to find a high-efficiency multifunctional catalyst for simultaneous removal of SO2 and NO x from flue gas. In addition, we also studied the effects of temperature and discharge power on the SO2 and NO x oxidation fraction to find the optimum operation condition. The investigated catalysts are NiO/TiO2,V2O5/TiO2, and TiO2. The discharge power varies from 9 to 15 W, and the reaction temperature range is 200−450 °C. The experimental results show that NiO/TiO2 is the best among the three catalysts. Meanwhile, temperature and discharge power have a positive influence on SO2 oxidation in the case of using NiO/TiO2, while the effects on NO x and NO are negative.