BackgroundType 2 diabetes (i.e. non-insulin-dependent, T2D) is a chronic, multifactorial, metabolic disorder typical of late adulthood characterised by less effective hormone insulin efficiency at lowering blood sugar. The World Health Organization reports that type 2 diabetes accounts for 85-90% of all cases of diabetes in the World [1].There are many different mechanisms that contribute to the onset of T2D [2], therefore research is focusing on the simultaneous observation of several factors such as

Background The aim of a recent research project was the investigation of the mechanisms involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the development of a computational model that recapitulates the aetiology of the disease and simulates the immunological and metabolic alterations linked to type-2 diabetes subjected to clinical, physiological, and behavioural features of prototypical human individuals. Results We analysed the time course of 46,170 virtual subjects, experiencing different lifestyle conditions. We then set up a statistical model able to recapitulate the simulated outcomes. Conclusions The resulting machine learning model adequately predicts the synthetic dataset and can, therefore, be used as a computationally-cheaper version of the detailed mathematical model, ready to be implemented on mobile devices to allow self-assessment by informed and aware individuals. The computational model used to generate the dataset of this work is available as a web-service at the following address: http://kraken.iac.rm.cnr.it/T2DM.