Background: The aim of this study was to compare the level of inammatory parameters in 3 different groups of COVID-19 patients depending on severity of clinical manifestations and to dene which inammatory parameter can be used as predictor of clinical severity and outcome. A total of 51 subjects was included in this study by retrospective review of theMethods: documentation at the Clinic for Infectious Diseases of University Clinical Hospital Mostar. The following data were collected: demographic, clinical symptoms, complications, therapy, and the level of inammatory parameters (C-reactive protein at the admission, procalcitonin, leukocytes, relative neutrophils count, relative lymphocyte count). Depending on the value of paO2/O2 patients were separated into 3 groups: mild, moderate and severe group. Data entry into the tables was followed by statistical data processing using IBM SPSS Statistics v.26 and Microsoft Excel 2013. Most frequent symptoms were fever (82% of all subjects), cough (61%), trouble breathing (55%), shortness ofResults: breath (43%), chest pain (27%), muscle pain (25%), diarrhea (20%), vomiting (6%) and headache (6%). The overall mortality of this study was 35%, with a statistically much higher mortality in severe patients. Also C-reactive protein levels were higher in severe patients. Conclusions: Levels of C-reactive protein on admission were signicantly higher in patients who developed a severe clinical manifestations. Also, mortality in severe patients was statistically higher than the remaining 2 groups of patients. CRP is reported as a prognostic factor in the severity of clinical manifestations and mortality of hospitalized COVID-19 patients.

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Background:The aim of this study was to determine the presence of coagulation parameter disorders in patients hospitalized due to COVID-19 and to investigate the relationship between the abnormalities of coagulation parameters and the final outcome. Methods: We performed a retrospective cohort study of 81 patients admitted to the University Clinical Hospital Mostar, due to respiratory infection by SARS-CoV-2, in the period from March 15th to May 15th, 2021. Subjects were divided into two groups according to the final outcome. We analyzed age, sex, comorbidity frequency and parameters of coagulation function. Main findings: Of the 81 patients, 42 died and 72.7% died in the Respiratory Center (p<0.001). Two-thirds of the respondents were male. The mean age of all respondents was 72.88±14.21 years. Nonsurvivors were significantly older than survivors (p=0.002). Previous chronic disease was confirmed in 84% of the subjects and the most common comorbidity was arterial hypertension. D-dimers were elevated in 95% of the subjects. Non-survivors had a statistically significant prolongation of APTT in seconds (p=0.005) than survivors, while in other coagulation parameters, there was no statistical significance with respect to the severity of the clinical status and the final outcome. Principal conclusions: SARS-CoV-2 infection is associated with abnormalities in the parameters of coagulation function. Moreover, APTT is an important factor for prognosis assessment in patients with COVID-19.