This article examines the potential for non-invasive measurement of elevated levels of erythrocyte aggregation in vivo, which are linked to a higher risk of inflammatory processes. The study proposes the use of a dynamic light scattering approach to measure aggregability. The mDLS sensor modules consist of VICEL and two photodiodes, and two of these modules are placed on an inflatable transparent cuff. The cuff is then fitted to the subject's finger root, with one sensor module placed on each side of the root. Blood flow is temporarily halted for one minute using over-systolic inflation of the cuff, and signals from both sensors are recorded. Three groups of subjects were studied: a control group of 65 individuals, a group of 29 hospitalized COVID-19 patients, and a group of 34 hospitalized patients with inflammatory diseases. The experimental results demonstrated significant differences in signal kinetic behavior between the control group and the other two groups. These differences were attributed to the rate of RBC aggregation, which is associated with inflammation. The study underscores the potential for non-invasive diagnostic tools to assess inflammatory processes by analyzing RBC aggregation.

This article examines the potential for non-invasive measurement of elevated levels of erythrocyte aggregation in vivo, which are linked to a higher risk of inflammatory processes. The study proposes the use of a dynamic light scattering approach to measure aggregability. The mDLS sensor modules consist of VICEL and two photodiodes, and two of these modules are placed on an inflatable transparent cuff. The cuff is then fitted to the subject's finger root, with one sensor module placed on each side of the root. Blood flow is temporarily halted for one minute using over-systolic inflation of the cuff, and signals from both sensors are recorded. Three groups of subjects were studied: a control group of 65 individuals, a group of 29 hospitalized COVID-19 patients, and a group of 34 hospitalized patients with inflammatory diseases. The experimental results demonstrated significant differences in signal kinetic behavior between the control group and the other two groups. These differences were attributed to the rate of RBC aggregation, which is associated with inflammation. The study underscores the potential for non-invasive diagnostic tools to assess inflammatory processes by analyzing RBC aggregation.