The investigation carried out during two successive seasons of 2018 and 2019 to study the effect of various natural plant extracts; synthetic chemicals and certain combinations on yield and cluster weight of Ruby Seedless grape cultivar. The natural plant extracts included Moringa, Fulvic acid, Chitosan, Turmeric extract, Aloe vera and Seaweed extract, while the synthetic chemicals were GA 3 , Hydrogen peroxide (H 2 O 2 ) , Salicylic acid, Mepiquat chloride, Micronutrients and free amino acids. As well as certain combined treatments. The results revealed that most treatments significantly increased both yield and cluster weight. The best natural treatments in this regard were Chitosan extract; Seaweed extract and Fulvic acid while Salicylic acid recorded the best results of chemical compound. While; from the combination treatments, free amino acids + Fulvic acid produced the highest yield and cluster weight.