This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl 3 . The rats were distributed into six groups of five rats each. The drug and extract administration lasted for seven days, thereafter the animals sacrificed. The results indicated that oral dose of 100 mg/kg bw extracts of H. acida did not show any significant (p>0.05) change in testosterone levels when compared with both normal and negative control. Ethanolic extract showed non-significant (p>0.05) increase on Luteinizing hormone (LH) when compared with both normal and negative control group. Administration of AlCl 3 caused a significant (p<0.05) decrease in Follicle Stimulating Hormone (FSH), while the plants extracts caused a non-significant increase when compared with the negative control. Thiobarbituric Acid Reactive Substance (TBARS) increased significantly (p<0.05) in negative control, but decreased significantly in groups treated with aqueous and ethanolic extract of H. acida when compared with the negative control. Induction of AlCl 3 -toxicity caused a non-significant (p>0.05) alterations of most of the haematological parameters evaluated, but administration of the plant extracts was able to mildly ameliorate these effects (especially on RBC and Hb). The result of this study shows AlCl 3 toxicity causes alterations of LH, FSH and TBARS, but aqueous and ethanolic stem bark extracts of H. acida may possibly ameliorate the alteration. Also, AlCl 3 -toxicity mildly influences the synthesis of certain haematological indices, but the extracts may modulate some of this interference.

This study was conducted to determine the effect of ethanolic leaf extract of Vitex doniana on the toxicity induced by aluminium chloride in male Wistar albino rats. A total of 15 male albino rats were used for the study and toxicity was induced using 100mg/kg body weight (bw) AlCl3. They were grouped into three (five rats in each group): normal control, AlCl3 control and AlCl3 + 100mg Vitex doniana respectively. The normal control group was fed with standard rat chow only, while the AlCl3 control group was orally administered 100mg/kgbw AlCl3, and the AlCl3 + V.D group was orally administered 100mg/kgbw extract following administration of AlCl3. The study was conducted for 7 days after which the effect of the extract was assessed following the animal sacrifice. Oral dose of 100mg/kg bw extract of Vitex doniana did not show any significant change in TBARS level of liver and testes in the experimental groups, while the AST, ALT and ALP levels in AlCl3 control and AlCl3 + 100mg Vitex doniana showed significant increase (p<0.05) and non-significant increase (except ALT which increased significantly) with control group respectively. The PCV and Hb levels did not show any significant (p>0.05) change from the control group, while there was no significant difference in bilirubin level among the different experimental groups. More research should therefore be done on this study to further understand the usefulness of ethanolic leaf extract of Vitex doniana, and encourage its application in herbal medicine.