Imaging photoplethysmography (iPPG) is a contact-free monitoring of the cutaneous blood volume pulse by RGB (red-green-blue) cameras. It detects vital parameters from skin areas and is associated to cutaneous perfusion. This study investigated the use of iPPG to quantify changes in cutaneous perfusion after major surgery. Patients undergoing coronary artery bypass grafting (CABG) were scanned before surgery and in three follow-up measurements. Using an industrial-grade RGB camera and usual indoor lighting, a contact-free imaging plethysmogram from the chest was obtained. Changes of the iPPG signal strength were evaluated in view of both the operation itself as well as the unilateral preparation of the internal thoracic artery (ITA) for coronary artery grafting, which is the main blood source of the chest wall. iPPG signal strength globally decreased after surgery and recovered partially during the follow up measurements. The ITA preparation led to a deeper decrease and an attenuated recovery of the iPPG signal strength compared to the other side of the chest wall. These results comply with the expected changes of cutaneous perfusion after CABG using an ITA graft. iPPG can be used to assess cutaneous perfusion and its global changes after major surgery as well as its local changes after specific surgical procedures.