Background and ObjectiveaaAs sleep is a predictor of quality of life, studying sleep health and measurement is important. Actigraphy as a physiologic measure based on monitoring an individual's movement has also been increasing in use as it has several advantages over traditional self-reports. This study aimed to report the research trends of sleep and actigraphy using a bibliometric and keyword analysis. MethodsaaUsing topic search queries, this study collected data from 3955 publications published between 2004 and 2020 and listed in the Web of Science Core Collection. A text-mining unstructured data analysis was performed using author keywords and a bibliographic analysis. ResultsaaStudies on sleep and actigraphy have been actively conducted in the fields of neurosciences and neurology but not in other fields. A gradual increase in publication and the steep increase in citations related to this topic occurring during the period considered. By clustering the author keywords, the analysis revealed five clusters: 1) monitoring physical activity and blood pressure, 2) measuring sleep quality, 3) insomnia and cognitive behavioral therapy for adolescents and children, 4) disorders and circadian rhythms, and 5) shift work. The leading research cluster has changed over the time. ConclusionsaaWith the increase in the number of studies and citations on sleep and actigraphy over the past 16 years, the trend of sleep and actigraphy studies have shifted from a focus on sleeprelated psychiatric disorders to a focus on cognitive behavioral therapy for children and adolescents and, more recently, the measurement of sleep quality.