Percutaneous needle aspiration and lavage is effective in the short term and in the long term in calcific tendinitis of the shoulder, with results similar to or better than those published for other techniques, and it is only slightly invasive and painful. Progress after treatment may include a transitory period of recurrence of the pain.

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Background:In our population the prevalence of hypovitaminosis D is high. A recent cross-sectional observational study conducted in Spain shows that 63% of postmenopausal women who receive osteoporosis (OP) therapy and 76% who do not receive treatment had 25 (OH) D levels below 30 ng / mL1.The latest studies show a relationship between hypovitaminosis D and the development of systemic inflammatory and tumor diseases, determined by the presence of receptors in various tissues, including breast.Objectives:To determine which levels of serum 25 (OH) D, and secondarily calcium, phosphorus, PTH and CTX, present 200 patients diagnosed with breast cancer and taking hormonal treatment, referred to a monographic OP consultation of a tertiary hospital for the assessment of their bone metabolism, and if these values differ from what is expected for the general population.Methods:Retrospective cross-sectional study of 200 women diagnosed with breast cancer receiving treatment with aromatase inhibitors (AI), performed in a tertiary hospital. Blood levels of vitamin D, calcium, phosphorus, PTH and CTX have been collected, as well as other variables and risk factors.Results:200 patients with a mean age of 64.8 years and an ED of 9.5 were collected. The median is 64.5 (Q1 58 and Q3 72).The vitamin D levels presented by the study patients were <10 ng/mL in 13 patients (6.67%), 11-20 ng/mL in 50 (25.64%), 21-30 ng/mL in 68 (34.87%), 31-70 ng/mL in 62 (31.79%), and> 70 ng/mL in 2 (1.03%). This implies that in 67.18% of the patients they had values below the optimal range.92.31% of patients (180) presented PTH values within the normal range and only 7.69% presented values above normal.The serum calcium and phosphorus levels of the patients selected for the study had ranges within normal (99.49%) except 1 case that presented high values (0.51%) for both.The values of CTX (carboxyterminal telopeptide used as a marker of bone resorption) were in the normal range in 81.96% of patients (159), low values in 0.52% (1) and values above the normal range by 17.53% (34).Conclusion:The prevalence of insufficient levels of vitamin D in our study (Breast cancer + AI) is not greater than that estimated for the general population according to various studies.Our study found that 67.18% of patients (2/3 of the selected population) had values below those considered optimal (<30 ng / mL) and 32% had values <20.Only 7.69% of the patients presented PTH values above the normal range.In 82% of patients, CTX used as a marker of bone resorption had normal values.References:[1]Quesada Gomez JM, Díaz Curiel M, Sosa Henríquez M, Malouf-Sierra J, Nogués-Solan X, Gómez-Alonso C, et al. Low calcium intake and insufficient serum vitamin D status in treated and non-treated postmenopausal osteoporotic women in Spain. J Steroid Biochem Mol Biol. 2013;136:175-7.[2]Jian Sun et al., Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients; Clinical Rheumatology (2019) 38:2509–2518Disclosure of Interests:None declared

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BackgroundLupus Nephropathy (LN) is an important cause of morbidity and mortality in patients with Systemic Lupus Erythematosus (SLE). The goal of LN treatment is to suppress inflammation and preserve renal structure and function to prevent progression to kidney failure, in addition to minimizing side effects. Currently therapy for severe LN is based on high doses of glococorticoids and differents immunosuppressive drugs.ObjectiveTo determine the response time and immunosuppressive drugs used in a series of patients with LN.MethodsRetrospective analysis of Lupus patients in a single center with renal disease. The variables recorded were: the number of immunosuppressive drugs used from the diagnosis of LN until remission and the response evaluated regarding 24 hour proteinuria (achieve remission, improvement greater than or equal to 50% respect to baseline and/or no improvement).ResultsIn a series of 80 patients with SLE, 17 were diagnosed with NL, and of these, 14 proliferative diffuse glomerulonephritis (GN lV). The sample consists of 2 men and 12 women between 30 and 65 years of age, with a follow-up time of 6 to 55 months and 9 Caucasian and 5 Latin Americans. All patients were treated with hydroxychloroquine (HCQ), antihypertensive and corticosteroids. The immunosuppressant treatment used was: mycophenolate mofetil, azatioprine, cyclophosphamide, tacrolimus and rituximab. Considering that the time of follow-up of patients varies, each temporary space was analyzed according to the number of patients. Figure 1 shows that at 6 months, 38% of patients had an improvement >50% and 7.7% of patients achieved remission. After one year of treatment, 42% of patients presented improvement >50% and 17% achieved remission but in 23% of patients two changes of immunosuppressive treatment was needed. At 24 months, 50% of patients improved >50% and 25% achieved remission; in 13% of patients it was necessary to make another treatment change. Finally, after 24 months, it was observed that 50% of patients achieved remission, 33% of patients presented an improvement >50% and only 17% presented renal failure, and it was necessary to make another treatment change. Globally, in 36% of patients 1 or more changes of immunosuppressive treatment were necessary to achieve improvement >50% or remission.Abstract 263 Figure 1Response time of the LN with immunosuppressive treatment regarding to 24h proteinuria. Blue: normal value of proteinuria 24 h, Red: improvement 50% compared to baseline, Green: no improvement or remissionConclusionsPatients who do not experience an improvement >50% in a period of 6 months are more likely to improve if a change in immunosuppressive treatment is made. It is necessary to extend the series to reach conclusions with statistical value.Funding Source(s):No funding