Activated by AMP-dependent and -independent mechanisms, AMP-activated protein kinase (AMPK) plays a central role in the regulation of cellular bioenergetics and cellular survival. AMPK regulates a diverse set of signaling networks that converge to epigenetically mediate transcriptional events. Reversible histone and DNA modifications, such as acetylation and methylation, result in structural chromatin alterations that influence transcriptional machinery access to genomic regulatory elements. The orchestration of these epigenetic events differentiates physiological from pathophysiological phenotypes. AMPK phosphorylation of histones, DNA methyltransferases and histone post-translational modifiers establish AMPK as a key player in epigenetic regulation. This review focuses on the role of AMPK as a mediator of cellular survival through its regulation of chromatin remodeling and the implications this has for health and disease.

Demam Berdarah Dengue (DBD) masih merupakan salah satu masalah kesehatan masyarakat di Indonesia. Salah satu upaya yang paling tepat dalam pencegahan dan pemberantasan DBD adalah kegiatan pemberantasan sarang nyamuk (PSN). Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap dengan perilaku keluarga tentang PSN DBD. Jenis penelitian deskriptif analitik dengan desain penelitian cross sectional study pada 68 Kepala Keluarga dengan teknik pengambilan sampel adalah Simple Random Sampling. Penelitian ini dilakukan pada tanggal 29 Agustus sampai 9 September 2017 di korong Sarang Gagak wilayah kerja Puskesmas Enam Lingkung Kabupaten Padang Pariaman. Pengumpulan data dengan menggunakan kuesioner. Data diolah secara univariat dalam bentuk tabel distribusi frekuensi dan bivariat dengan uji chi- square. Hasil penelitian ini adalah 52,9% keluarga mempunyai pengetahuan yang rendah, 51,5% keluarga mempunyai sikap yang negatif dan 61,8% mempunyai perilaku yang kurang baik tentang PSN DBD. Terdapat hubungan yang bermakna antara pengetahuan (p=0,000) dan sikap (p=0,003) dengan perilaku keluarga tentang pemberantasan sarang nyamuk demam berdarah dengue di korong Sarang Gagak. Pengetahuan dan sikap mempengaruhi perilaku keluarga tentang PSN DBD. Diharapkan pada masyarakat hendaknya lebih men

Kualitas pendidikan di Indonesia hingga saat ini belum bisa dikatakan baik. Hal ini dikarenakan masih banyak sekolah yang belum memiliki sarana dan prasarana yang lengkap serta rendahnya kualitas guru dan prestasi siswa. Hal ini tentu menjadi penyebab rendahnya kualitas pendidikan di Indonesia.

Background: Chronic obstructive pulmonary disease (COPD) is a disease that is a problem throughout the world where its prevalence, morbidity and mortality are increasing every year. The high number of COPD visits is due to persistent and progressive shortness of breath complaints. Existing pharmacological therapies for COPD have not shown improvement in the long-term decline in pulmonary function that is a hallmark of COPD. It is very necessary for companion therapy that is non-pharmacological treatment is expected to be able to complete pharmacological treatment in reducing shortness of breath of COPD patients with pursed-lip breathing exercise.Methods: This study uses a quassy experiment design with two group pretest and posttes design approaches. This study was in obstructive pulmonary disease patients in the lung hospital in West Sumatra with an intervention group of 16 and a control of 16 respondents. Data analysis using univariate and bivariate using independent t-test statistics.Results: The results showed the average decrease in shortness of breath in the control group without pretest 3.19 and posttest 2.56 in the pretest pursed lip breathing exercise intervention group 3.19 and posttest performed 1.69. Test statistic p-value 0.026.Conclusions: There is an effect of pursed lip breathing exercise on reducing the level of shortness of breath in patients with chronic obstructive pulmonary disease.