Abstract. The strategy of production and application of biologically synthesized nanomaterials have become an integral part of nanotechnology. The present study involves the aqueous extraction of root (Pongamia Pinnata) and analyzing of phytochemical compounds and functional groups present in plant root by FTIR. The synthesis of silver nanoparticles was prepared by root extract (Pongamia pinnata); confirmation and characterization of synthesized silver nanoparticles was done by UV-VIS Spectroscopy, SEM and EDAX. Preparation of Nanogel was done by varying the concentrations of silver nanoparticle and paraffin wax. The best of 3 were selected for the further studies like in-Vitro anti-inflammatory, drug release and degradation studies; in respective of results observed in vitro drug release method showed that the nanogel was dispersed from dialysis membrane according to the time interval, in vitro degradation rate varies according to the concentration of nanogel preparation (Gel 1-40%,Gel 2-56% & Gel 362%),in vitro anti-inflammatory studies of membrane stabilization and protein denaturation showed no much of significant difference between standard drug aspirin along with prepared nanogel.

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