SOEP, Biographische Erhebung, Haushaltspanel, Paneldesign, Kohortenstudie, Lebensverlauf, Stichprobenziehung, Hochrechnung, Datenstruktur, Service, SOEP, Biographical survey, Household panel, Panel design, Cohort study, Life course, Life span, Sampling procedure, Weighting, Data structure, Service,

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The densely innervated human cornea is the only superficial tissue of the human body in which nerve fibres are accessible in vivo by corneal confocal microscopy (CCM). Morphological parameters of the corneal sub-basal nerve plexus (SNP) derived from CCM images can potentially serve as a sensitive biomarker for early diagnosis of various neurodegenerative diseases. The evaluation of a single image with a typical field of view of 0.16 mm2 is insufficient for robust morphometric assessment. Mosaicking approaches have therefore been proposed to examine the SNP on a larger scale. Here we present a highly automated technique that significantly facilitates the generation of mosaic images of the SNP and is suitable for clinical tests.

Microinjection molding is a mass production method to fabricate affordable optical components. However, the intense nature of this process often results in part deformation and uneven refractive index distribution. These two factors limit the precision of replicated optics. In order to understand the influences of injection molding on freeform optical devices, in this study, finite element method (FEM) was employed to investigate the miniature microinjection-molded Alvarez lenses. In addition, an innovative metrology setup was proposed to evaluate the optical wavefront patterns in the molded lenses using an interferometer-based wavefront measurement system. This measurement setup utilized an optical matching liquid to reduce or eliminate the lenses' surface power such that the wavefront pattern with large deviation from the freeform lenses can be measured by a regular wavefront setup. The FEM simulation results were also used to explain the differences between the nominal and experimentally measured wavefront patterns of the microinjection-molded Alvarez lenses. In summary, the proposed method combining simulation and wavefront measurements is shown to be an effective approach for studying injection molding of freeform optics.

We present the design of a varifocal freeform optics consisting of two lens bodies each with a helicaltype surface structure of azimuthally varying curvatures. This arrangement allows for tuning the optical refraction power by means of a mutual rotation of the lens bodies around the optical axis. Thus, the refraction power can be tuned continuously in a defined range. The shape of the helical-type surfaces is formed by a change in curvature subject to the azimuthal angle α. At the transition of the azimuthal angle from α ¼ 2π to α ¼ 0, a surface discontinuity appears. Since this discontinuity will seriously affect the imaging quality, it has to be obscured. In the initial state, i.e., zero-degree rotation, the curvatures of the opposing surfaces result in a specific refraction power, which is constant over the entire circular aperture. Rotating one of the lens bodies by an angle φ around the optical axis will change the opposing curvatures and result in a change of refraction power. Two circular sectors with different tunable optical refraction powers are formed, thus resulting in a tunable bifocal optics. Obscuring the minor sector will result in a tunable monofocal rotation optics. In contrast to conventional tunable lens systems, where additional space for axial or lateral lens movement has to be allocated in design, rotation optics allowing for a more compact design. A performance analysis of the rotation optics based on simulations is presented in dependence on aperture size as well as approaches to compensate for spherical aberrations. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.