TREX2 is a 3′-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-regulated or lost in human squamous cell carcinomas (SCCs). Moreover, we identified SNPs in the TREX2 gene that were more frequent in patients with head and neck SCCs than in healthy individuals. In mice, TREX2 deficiency led to enhanced susceptibility to UVB-induced skin carcinogenesis which was preceded by aberrant DNA damage removal and degradation as well as reduced inflammation. Specifically, TREX2 loss diminished the up-regulation of IL12 and IFNγ, key cytokines related to DNA repair and antitumor immunity. In UV-treated keratinocytes, TREX2 promoted DNA repair and passage to late apoptotic stages. Notably, TREX2 was recruited to low-density nuclear chromatin and micronuclei, where it interacted with phosphorylated H2AX histone, which is a critical player in both DNA repair and cell death. Altogether, our data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response.

This article compares Spain and Sweden, dissimilar in their welfare/care, migration and employment regimes; however, both have experienced expansions of private markets for personal household services where migrants are over-represented. Using Sen’s capabilities framework as a point of departure, we explore the extent to which regime differences shaping the dynamics of personal household service markets are reflected in the capabilities and well-being of migrants employed in them. Despite variations in employment regimes and market structures, we found more similarities than differences in capabilities and well-being. Institutional contexts mattered for the access to entitlements and capabilities for alternative choices in employment, discernible in the more positive perceptions of future possibilities and potential agency to leave the sector among migrants in Sweden than in Spain. The analysis is based on 90 semi-structured interviews, as well as findings from two national migrant surveys and interviews with stakeholders.

This article explores the impact of the Great Recession on migrant domestic workers in Spain. We argue that the domestic service sector’s relative resistance to job destruction has transformed it to some extent into a refuge activity for unemployed women from other sectors, both migrants and native Spanish workers. This leads to intensified competition over jobs and increasing stratification among domestic workers, with serious consequences both for migrant women’s opportunities to make a living in Spain and for their migration projects at an international level. Based on 90 in-depth interviews with female migrant domestic workers and stakeholders, we find that this group of workers has been seriously affected by unemployment, underemployment, and worsened job conditions. As a consequence, new and already settled migrants find the chances to gain their livelihood in Spain substantially reduced, and many of those who migrated in order to support the family back home through remittances, or to save some money and eventually return, are at present unable to do so.

The importance of transnational migration projects for international development has been increasingly recognized over the past decades. Migrants who move from the Global South or East to work in low-wage sectors such as construction, agriculture or domestic services in wealthier countries may contribute both to growth in the receiving countries and socioeconomic development in their countries of origin. Parallel to scholarship on migration and development, research on the transnationalization of domestic work generally assumes that growing care needs and increasing demand for private household services in Western societies imply a continuing demand for migrant labour. However, since the global financial crisis broke out in 2008, unemployment among migrant workers has increased dramatically in many immigrant-receiving countries, Spain being among the most severely affected. Job destruction has so far been lower in the domestic sector than in other sectors occupying large numbers of migrant workers. Yet, we find that migrant domestic workers in Spain are affected by the recession both in terms of unemployment or underemployment and deteriorating job conditions, with transnational consequences such as loss of remittances. Many migrants find themselves in a situation of "standby," trying to subsist while waiting for the recession to end.

Italy and Spain, as countries of recent immigration and high irregularity rates, have struggled to adapt their statistical system, especially their population registers, to adequately reflect the presence of an increasing number of immigrants in their territory. The population registers of the two countries have adapted differently to these changing realities: Spain introduced significant improvements in Padrón which have increased its coverage and accuracy. This is still not the case in Italy, making it necessary to resort to non-random sampling methods. The paper discusses the methodological implications of these differences and evaluates different methodological solutions based on both random and non-random sampling methods in both countries.