Acne vulgaris is a skin condition characterized by the inflammation or hyperactivity of sebaceous glands on the skin, which results in the creation of comedones, lesions, nodules, and perifollicular hyper keratinization. Increased sebum production, follicular blockage, and bacterial colonization may contribute to the disease etiology. It primarily affects the T-zone of the face and trunk and is frequent throughout puberty. Environmental factors, hormonal imbalance, and genetic predisposition can alter the severity of disease. Its mental and monetary effects can be problematic for the society. In this study, we examined the role of isotretinoin in the treatment of acne vulgaris based on evidence from prior research. Isotretinoin has been recognized as an effective treatment for acne vulgaris, particularly in cases that have been resistant to previous medications or have resulted in scarring, according to gathered data. Oral isotretinoin inhibits the proliferation of Propionibacterium acnes, a critical factor in the development of acne lesions; also it has been shown to be effective in reducing the number of Propionibacterium-resistant patients and to regulate sebum production and reduce sebaceous gland size more effectively than other treatment options.so result in general improvements in skin clarity and acne severity and reduce inflammatory in 90% of patients. In addition to its efficacy, the majority of patients have showed that oral isotretinoin is well tolerated. Despite the fact that it is linked to a number of potential harmful effects, Skin dryness was the most common side effects reported by patients that it can be managed with the aid of suitable monitoring and administration procedures.