African leaf plants (Vernonia amygdalina Del.) contain many secondary metabolites, one of which is flavonoids. African leaves are commonly used in traditional medicine. This study aims to determine the extract of African leaf plants can be formulated in the preparation of effervescent granules and is suitable for the criteria for good granules. African leaves were macerated using 96% ethanol as solvent and evaporated to obtain a thick extract. Then, the African leaf extract obtained was formulated into effervescent granules with a concentration of 10%. The production of effervescent granules is based on the principle of the wet granulation method. The results showed that the evaluation of the effervescent granules of African leaf extract was only suitable for the requirements of the haussner factor, porosity, particle size distribution, moisture content, angle of repose, dispersion, and pH but did not suitable for the requirements of compressibility and flowability. The flavonoid content in the African leaf extract is 96,2276% while the effervescent granule is 94,634%.94,634%.