The paper industry is an activity that have a large impact on the quality of natural resources. The large amount of water used has an impact on the wastewater generated. Untreated liquid waste can cause pollution in water bodies (rivers). Wastewater treatment with Up flow Anaerobic Sludge Blanket (UASB) is able to process wastes with high COD content in the paper industry. This paper provides a basic review and UASB research that has been carried out in the wastewater treatment of the paper industry.