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The aim of this meta-analysis was to examine the clinical effectiveness of miniscrew implants (MI) used for anchorage reinforcement compared with that of conventional orthodontic means, as well as to assess the success rates of MIs and the possible risk factors affecting their clinical effectiveness. Literature searches were conducted, and, using specific inclusion and exclusion criteria, two independent investigators performed data extraction and analysis. Overall pooled estimates with 95% confidence intervals (CI) were obtained with the random-effects model. Eight out of 3183 original papers met the inclusion criteria. The mean difference of anchorage loss between the MI and conventional anchorage group was -2.4 mm (95% CI = -2.9 mm to -1.8 mm, p = 0). MIs significantly decreased or negated loss of anchorage. Anchorage loss seemed to be less in the mandible, when the MIs were inserted between the second premolar and the first molar, when 2 MIs were inserted per patient jaw, when they were directly connected, as well as when treatment lasted more than 12 months. MIs presented a success rate of 87.7%, with no significant differences between the various subgroups. However, the results of this meta-analysis should be interpreted with some caution because of the number, quality, and heterogeneity of the included studies.

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Exposure to fixed orthodontic appliances did not show a significant effect on salivary parameters related to inflammation or stress, with the exception of a significant but transient pH decrease after bonding.

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