Diabetic nephropathy is the major cause of severe renal impairment and even chronic terminal renal failure requiring dialysis. Blood viscosity is clearly modified in diabetic patients, and particularly in those with severe renal impairment The purpose of this study is to highlight blood viscosity values at different shear rates in patients with diabetic nephropathy compared to the control group. There is a significant increase in blood viscosity in patients with definite renal impairment.

The Metabolic syndrome (MetS) is considered as an association of the abdominal obesity, abnormal metabolism of the lipids and glucose (high level of triglycerides, low level of HDL-cholesterol and high level of glycemia) and high values of blood pressure, determined by an underlying mechanism of insulin resistance. As a result of environmental-gene interaction, MetS is associated with unhealthy nutrition, smoking, alcohol abuse, lack of physical activity, shorter sleep duration and desynchronization of the circadian rhytm caused by working in shifts. The aim of this article is to review the effects of working in shifts on the MetS through the epidemiological evidence and the perspective of the physiopathological mechanisms.

Chronic granulomatous disease is a diverse group of hereditary diseases characterized by neutrophils incapacity or difficulty to form reactive oxygen compounds, most important, the superoxide radical, used to kill certain pathogens. The consequence is recurrent infections with germs with normally low pathogenicity and formation of supurative granulomas. The authors present a pathology case of immunodeficiency rarely seen in pediatrics: chronic granulomatous disease in a 2 months old infant. The positive diagnosis was based on clinical presentation, dominated by lymphadenopathy, pemphigoid skin lesions, bilateral ear secretion, growth failure, hepatomegaly. Physical presentation correlated with laboratory studies (Bursttest), chest radiography and CT imaging, moderate inflammatory syndrome, low platelets level and the presence of fibrin monomers suggested a neonatal sepsis having on the background a X-linked immunodeficiency (the patient being the only male survivor in his family, with 4 healthy sisters). The specific feature in this case was early onset of the disease, with clinical, but most important, pulmonary radiological aspect characteristic for chronic granulomatous disease. The prognosis was poor; the baby is readmitted in the hospital after 2 months and he dies, having clinical aspect of sepsis unresponsive to the applied intensive therapy. The histological findings enhanced numerous pulmonary and hepatic microabscesses.

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The study aims to analyze the health effects caused by chronic exposure to elevated levels of nitrates in the water in order to improve prevention of some diseases. We analyze water quality from two villages of Constanta County in the period 2006-2012 and we take data about chronic diseases from family doctors of these localities. Analyzes on water samples were made in the laboratory of the Public Health Department. We found a significant increase of prevalence for chronic diseases in locality exposed to nitrates.