Objectives:The aim of this study was to evaluate the trial of labor after caesarean (TOLAC) outcomes and determine its reliability by comparing it with elective repeat caesarean delivery (ERCD) and vaginal delivery.

Objective: Polycystic ovarian syndrome (PCOS) is a complex endocrinopathy that affects women in reproductive age. Although the pathogenesis is still unclear, the abnormal secretion of luteinizing hormone, follicular-stimulating hormone due to the alterations in hypothalamic-pituitary-gonadal (HPG) axis, is demonstrated to be the major cause. Kisspeptin is a hypothalamic peptide under the influence of KISS1 gene. Based on the fact that it affects gonadotropin-releasing hormone (GnRH) secretion, it is thought to play a role in the development of PCOS. Furthermore, kisspeptin may be determined as a possible biomarker for this syndrome. Due to the complex relationship between kisspeptin and the HPG axis, we aimed to reveal the association of serum kisspeptin level with PCOS in women. Material and Methods:The study was designed as a prospective study in Koru Ankara Hospital. A total of 88 women were included in the study. Forty four of them were diagnosed with PCOS according to the Rotterdam criteria. Serum kisspeptin measurements were performed using an enzyme-linked immunosorbent assay kit.Results: : In the present study, PCOS patients showed statistically significant lower serum kisspeptin levels compared to controls. Conclusion:Although kisspeptin is thought to play a role in PCOS by irregularly stimulating GnRH neurons, the definite mechanism remains still unclear. Clarifying the underlying role of kisspeptin in PCOS may provide valuable information for the future gene treatments.

Abstract Can prokineticin 1 be used as a biomarker in preeclampsia? Aim: Prokineticins are a group of peptides which play important roles in angiogenesis, hematopoiesis and reproduction. Prokineticin 1 (PROK1) is reported to be the major subgroup affecting the female reproductive development. PROK1 is secreted from the syncytiotrophoblasts and it prevents extravillous trophoblastic cell migration in the first trimester which predispose to the abnormal placentation and preeclampsia (PE). Hypoxia provokes the expression of PROK1 therefore its serum levels increase in pregnants with PE. The aim of the present study was to reveal the value of PROK1 as a marker of PE. Materials and Method: A total of 84 pregnant women were admitted to the study, and 43 of them were diagnosed with preeclampsia. 41 healthy pregnant women were included in the control group. The preeclampsia group was divided into two subgroups as mild PE (n=27) and severe PE (n=16). About 10 ml of venous blood was collected from each participant and dispensed into lithium heparin, and serum was obtained, which were stored at – 80 c until analyzed. Serum PROK1 measurements were performed by using an enzyme-linked immunosorbent assay (ELİSA). All tests were two-tailed, and p