Do commodity prices, real exchange rate and trade openness influence economic growth in South Africa? This question is fundamental to academic research since it forms the basis of macroeconomic policies. Therefore, the comprehension of such a relationship is vital which has ushered this study into investigating the effect of real exchange rate, commodity prices and trade openness on economic growth in South Africa from 1984-2019. The purpose of this study is to contribute to the diverse literature on macroeconomics and international trade in the continent and the rest of the world. To achieve this, the Johansen cointegration method and Vector Error Correction Model were employed. The Johansen cointegration method confirmed the existence of a long-run relationship among the variables. Commodity prices and trade openness positively influenced economic growth while real exchange rate inversely influenced economic growth. The Vector Error Correction Model also confirmed that the disequilibrium in the model can be corrected in 1 year 9 months. The study`s findings suggest a methodical monetary policy synthesis that controls both the commodity price stability and exchange rate that spurs economic growth.