Bovine mastitis is an udder inflammation mostly found in dairy cattle that causes enormous economic losses. Streptococcus is a bacterium that is often found in mastitis, including Streptococcus agalactiae, Streptococcus dysgalactiae, and Streptococcus uberis. These three species have lactoferrinbinding protein (LBP) as one of their virulence factors. Lactoferrin is a host innate immune protein that acts as antibacterial, immunomodulator, anti-adhesion, and has iron-binding properties. The LBP on the surface of Streptococcus could bind to lactoferrin produced by host cells. Uniquely, the three Streptococcus bacteria showed different responses to lactoferrin. The lactoferrin-LBP bound on S. agalactiae and S. dysgalactiae was known to inhibit their penetration ability into the host epithelial cells, on the contrary, in S. uberis it could enhance their ability to invade the cells. This paper aims to review the role of the lactoferrin-binding protein of Streptococcus in bovine mastitis.

Ringworm is one of the forms of zoonotic dermatitis caused by dermatophyte fungus that can be suffered by dairy cows. The disease usually does not cause death; however, it can decrease the productivity of dairy cows. This study aimed to determine the prevalence of dermatitis in dairy cows at BBPTUHPT Baturraden, Indonesia. This retrospective study was based on medical record data from January‒October 2021. Cows were diagnosed with ringworm if they show any clinical symptoms of grayish-white lesions or dark round-shaped patches with crusts, scales, hyperkeratosis, and alopecia of various sizes. The data obtained were analyzed descriptively. The results showed that cases of ringworm in January‒October 2021, had occurred in 114 out of the 1,099 dairy cows. Ringworm occurred throughout the year, and the 3 months with the most cases are March (36 cases), February (18 cases), and September (15 cases). To conclude, ringworm occurred in dairy cows at BBPTUHPT Baturraden, Indonesia from January to October 2021 with a prevalence of 10.4%.