No abstract

In this work, we obtain the numerical solutions of a 2D mathematical model of tumor angiogenesis originally presented in [Pamuk S, ÇAY İ, Sazci A, A 2D mathematical model for tumor angiogenesis: The roles of certain cells in the extra cellular matrix, Math Biosci 306:32–48, 2018] to numerically prove that the certain cells, the endothelials (EC), pericytes (PC) and macrophages (MC) follow the trails of the diffusions of some chemicals in the extracellular matrix (ECM) which is, in fact, inhomogeneous. This leads to branching, the sprouting of a new neovessel from an existing vessel. Therefore, anastomosis occurs between these sprouts. In our figures we do see these branching and anastomosis, which show the fact that the cells diffuse according to the structure of the ECM. As a result, one sees that our results are in good agreement with the biological facts about the movements of certain cells in the Matrix.

This work has been presented at the "International Conference on Mathematics and Engineering, 10-12 May, 2017, Istanbul, Turkey". In this paper we introduce a stability and Hopf bifurcation analysis of a reaction diffusion system which models the interaction between endothelial cells and the inhibitor. Then, we investigate the stability of the positive equilibrium solutions under some conditions. We also show the existence of a Hopf bifurcation and provide some figures to show that the equilibrium solutions are indeed asymptotically stable.

In this study, we investigate an SIRS epidemic model with logistic growth and information intervention.Firstly, the basic reproduction number R0 is defined and the main results are given in terms of local stability. Then, sufficient conditions for the global stability of endemic equilibrium are obtained. Finally, some numerical simulations are given to validate our theoretical conclusions.