Neurofibromatosis (NF) is a genetic and multisystemic disease with autosomal dominant transition. It can affect anesthesia applications by affecting more than one system. In the presence of neurofibromas in the airway, it can cause airway obstruction and difficulties in respiratory delivery during general anesthesia. The presence of tumors affecting the central nervous system makes spinal anesthesia risky. Anesthesiologists should act with awareness of each multisystemic complication when evaluating and managing patients. This case report aims to present our general anesthesia practice in an elective cesarean operation in a pregnant patient with neurofibromatosis type 1.

Acetaminophen (paracetamol) is a commonly used drug during pregnancy and is considered safe. However, it is among the most frequent agents of which overdoses are reported during pregnancy. The most important result of overdose use is hepatotoxicity, which can cause death. We herein present our approach to two pregnant cases we followed up in the intensive care unit due to acetaminophen intoxication.