We tested our working hypothesis that that liraglutide (LRG), a Glucagon-like peptide-1 (GLP-1) receptor agonist, may potentiate the e cacy of tramadol (TR), a synthetic opioid, in acute in ammatory process and may has profound therapeutic effects in controlling the local acute in ammation. The present study aimed to explore the possible anti-in ammatory actions of LRG, TR or their combination treatments by investigating the in ammatory signs such as pain hypersensitivity, edema and fever in carrageenan (CG)induced acute peripheral in ammation model in rats. The levels of several biomarkers for in ammatory status, angiogenesis and oxidative stress were also measured in in amed tissues. CG induced in ammation in the paws of rats caused identi ed by hypersensitivities, redness, edema and fever. LRG, TR or LRG+TR signi cantly improved the mechanical and cold allodynia, and reduced the edema and fever. LRG dramatically suppressed the in ammatory signs when compared to those of TR. In addition, co-administration of TR and LRG resulted in further reduction of sensitivity to cold and mechanical stimuli. E cacies of LRG, TR or LRG+TR on in ammatory induced reactions altered depending on inhibition rates in the biomarkers of in amed paws. Consequently, the suppressive actions of TR, LRG or TR+LRG combination in the in ammation induced hypersensitivities, edema and fever indicates that these drugs have signi cant anti-in ammatory potential with anti-hypersensitivities, anti-edema and antipyretic effects. LRG with anti-in ammatory actions may be a highly promising options for the management of in ammatory conditions or in ammatory related various diseases.