The paper by Robin Greinert et al.(1) touches upon a topic that is increasingly attracting interest from different perspectives (e.g., neurology, nephrology, ethics), but that at the same time is still in need of more focused and deeper analysis. To illustrate its relevance, the connection between chronic kidney disease (CKD) and cognitive impairment (CI) is the subject of an ongoing COST Action (CONNECT, Cognitive Decline in Nephro-Neurology, https://connectcost.eu/) which is devoted to clarify the causal mechanisms of cognitive decline in CKD in order to improve its clinical treatment, both in terms of prevention and care .