The current study investigated metal concentrations (Zn, Cd, Pb, Mn and Fe) in the habitat and body tissues (blood, liver and kidney) of common skittering frog Euphlyctis cyanophlyctis along the Korang River, Islamabad, Pakistan. Samples were collected from three selected contaminated sites and a reference site at four different occasions from October 2010 to March 2012. All studied metals showed elevated levels in river water, as well as in blood, liver and kidneys of frogs from all contaminated sites. Specifically, Mn showed significantly higher levels in all analysed matrices from contaminated sites compared to the reference site. Histological sections of frog livers exposed to elevated metals showed abnormal hepatocytes, while their kidney sections showed discontinuous glomeruli with dead or ruptured cells exhibiting improper shapes with cytoplasmic depositions. This study indicates that frogs inhabiting Korang River are at potential risk of metal toxicity from the environment.Key words: Dicroglossidae; histology; histopathology; metal bioaccumulation; pollution. Concentraciones de metales enEuphlyctis cyanophlyctis del río Korang en Islamabad, Paquistán. Se investigaron concentraciones de varios metales (Zn, Cd, Pb, Mn and Fe) en el hábitat y en tejidos (sangre, hígado y riñones) de la rana Euphlyctis cyanophlyctis a lo largo del río Korang en Islamabad, Paquistán. Se tomaron muestras de tres sitios seleccionados como contaminados y de una localidad de referencia en cuatro ocasiones entre octubre de 2010 y marzo de 2012. Todos los metales analizados mostraron niveles elevados en el agua del río y en la sangre, hígado y riño-nes de las ranas procedentes de los sitios contaminados. Los niveles de Mn fueron significativamente mayores en lugares contaminados con relación a la localidad de referencia. Los cortes histológicos de hígados de ranas expuestas a metales mostraron hepatocitos anómalos, mientras que las secciones de los riñones presentaban glomérulos discontinuos y células muertas o rotas con formas anómalas y deposiciones citoplasmáticas. Este estudio sugiere que las ranas que habitan en el río Korang están en riesgo de sufrir intoxicaciones a causa de los metales presentes en el medio.
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