Background The majority of childhood cancer survivors are at risk for treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. MethodsThe PanCareFollowUp Consortium was established in 2018, consisting of 14 project partners from ten European countries, including survivor representatives. The Consortium will develop two PanCareFollowUp Interventions, including a person-centred guideline-based model of care (Care Intervention) and eHealth lifestyle coaching (Lifestyle Intervention). Their development will be informed by several qualitative studies and systematic reviews on barriers and facilitators for implementation and needs and preferences of health care providers (HCPs) and survivors. Implementation of the PanCareFollowUp Care Intervention as usual care will be evaluated prospectively among 800 survivors from Belgium, Czech Republic, Italy and Sweden for survivor empowerment, detection of adverse health conditions, satisfaction among survivors and HCPs, costeffectiveness and feasibility. The feasibility of the PanCareFollowUp Lifestyle Intervention will be evaluated in the Netherlands among 60 survivors. Results Replication Manuals, allowing for replication of the PanCareFollowUp Care and Lifestyle Intervention, will be published and made freely available after the project. Moreover, results of the corresponding studies are expected within the next five years.

Background: Childhood cancer survivors (CCSs) have an increased risk of developing chronic health conditions.

The last four decades have seen great improvements in childhood cancer survival with 5-year survival rates increasing from 30% in 1970 to more than 80% at present. Currently, there are over 300,000 and 400,000 childhood cancer survivors living in Europe and the United States, respectively. 1-4 However, an unfortunate consequence of cancer treatment is that a majority of survivors are predisposed to an elevated life-long risk of developing health-related late effects. [5][6][7] Previous research has shown that health behaviors may have an impact upon a range of late effects. [8][9][10][11] For example, several studies have found associations between physical activity and a better cardiometabolic profile in adult survivors of childhood cancer. [8][9][10]12 In addition, a study by Tonorezos et al. showed that adherence to a Mediterranean diet pattern with high fruit and vegetable

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