No abstract

It is emphasized that the high frequency of adverse reactions is mainly connected with their uncontrolled intake. On the example of nimesulide (Nize) there analyzed the most important pharmacokinetic, biochemical, technological and other indicators that determine the uniqueness of the drug, determine its e ectiveness and safety, and explain the high commitment of patients and doctors. In particular, nimesulide has a long history of use, is the rst synthesized selective inhibitor of cyclooxygenase 2 and the only representative of sulfonanilide, in whose molecule the carboxyl group is replaced by sulfonanilide. is provides a protective e ect on the mucous membrane of the gastrointestinal tract. Due to the combination of various disintegrants, such as starch and sodium starch glycolate (super disintegrant), nimesulide is well absorbed. As a result, the rapid onset of analgesic e ect is 15 minutes a er administration.

No abstract

No abstract

No abstract