Objective. To assess the efficiency and tolerability of the Mardil Zinc Max, solution for external application, in topical therapy of patients with anogenital warts. Materials and methods. The study involved 58 women and 12 men at the age of 18 to 57 years old, suffering from anogenital warts. the diagnosis was confirmed by identification of human papillomavirus by the polymerase chain reaction in real time. All the patients were treated by the chemical destruction of anogenital warts with the 1.5% solution of zinc chloropropionate in 50% 2-chloropropionic acid (Mardil Zinc Max) by a single application of the solution on the pathological eruptions. The results of treatment were assessed in 2 weeks, in 1, 3, 6 and 9 months after the destructive therapy. Results. In 2 weeks 62 (88.6%) patients showed a clinical cure with complete tissue regeneration in the lesions, in 8 (11,4%) cases in areas of the preparation erosions were visualized in the epithelialization phase, and they completely resolved within 1 week. recurrences of anogenital warts were detected in 1 (1,4%) patient in the observation period up to 3 months and in 2 (2,8%) patients during 9 months after carrying out the destruction. Adverse drug events have not been identified in the course of therapy and follow-up. Conclusions. As a result of the treatment of anogenital warts with the Mardil Zinc Max high rate of performance and security was set (100%), as well as the low percentage (4,2%) of development of relapses.

Background. Acute upper respiratory tract infections (AURTIs) are common in children and can become recurrent, especially in patients with pharyngeal and/or palatine tonsil disorders. Aim. To evaluate the efficacy and safety of the herbal medicine of marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark and dandelion herb (Tonsilgon N) in preschool children with adenotonsillar disorders. Materials and methods. The study included 1876 children aged 2 to 5 years with a history of pharyngeal and/or palatine tonsil disorders and frequent recurrent respiratory infections. The subjects were randomized into two groups: Group 1 (n=940) received herbal medicine (10 drops 56 times daily) for 30 days, and Group 2 (n=936) received no additional medication. Efficacy and safety were evaluated after the therapy course and during the follow-up (3, 6, and 12 months after the treatment started). The assessment included nasopharyngeal endoscopy, cytological examination of nasal mucosa smears, measurement of soluble immunoglobulin A (sIgA) levels and lysozyme activity in nasal secretion. Results. After a course of therapy, a significant decrease in the incidence of AURTIs (p0.05), associated with a local immunity improvement, estimated by sIgA levels and lysozyme activity (p0.001 for both values versus the control group), was noted. By the end of the study, in 86.5% of patients of Group 1, the pharyngeal tonsil volume decreased from grade 2 to grade 1 of hypertrophy (p=0.000). The pharyngeal and palatine tonsil hypertrophy worsened in 83.6% of Group 2 patients. Conclusion. The study results showed that Tonsilgon N significantly reduced the incidence of AURTIs in children with pharyngeal and/or palatine tonsil disorders and frequent recurrent respiratory infections. This effect was associated with an increase in sIgA and lysozyme levels in the nasal secretion and a decrease in neutrophil counts, indicating an improvement in local immunity.

Cognitive linguistics, psychophysiology, cardiology, and pathological psycholinguistics have common theory and methodology. Clinical linguistics is a new area of research within cognitive science. The authors reviewed domestic and foreign studies of communicative disorders published in 1981–2022. The review focused on the cardiology, neurology, and pathological psycholinguistics of speech abnormalities, which demonstrated similar terminology and methods. The authors identified three research directions: 1) disorders associated with the period of intrauterine, intranatal, or early postpartum development; 2) age-related disorders; 3) disorders caused by a prior disease or brain injury. The language and communication profile of patients with cognitive impairments was different, but all aspects of language and communication fell into the field of psychophysiology, cardiology, and pathological psycholinguistics, thus remaining within an interdisciplinary paradigm. The review highlighted some terminological inconsistency of studies focused on the analysis of language and speech in cognitive linguistics. The authors proved that clinical linguistics is a separate branch of cognitive research that bridges a certain gap between theory and practice. They defined the main objectives of clinical linguistics as the coordination of the conceptual and terminological research apparatus, unification of methodology, and development of unified principles for language and communication research.