The article is devoted to one of the actual problems in obstetrics the pregnancy follow-up in patients with structural cardiac pathology. The presented clinical case demonstrates a patient with congenital heart disease, inherited obstetrical and gynecological history and the COVID-19 infection during pregnancy. Despite the clinically significant cardiac pathology, the patient delivered at full term of 37 weeks through the natural birth canal. The analysis of the clinical case allows us to conclude that a favorable prognosis of pregnancy and childbirth in women with aortic coarctation is possible with the pregnancy follow-up and delivery in specialized cardiology centers.

BACKGROUND: Cervical cancer is one of the four most common cancers today and is the second most common cancer among women in developing countries. According to World Health Organization estimates, in 2018, the number of new cases in these countries was 570,000 (84% of all new cases globally). About 311,000 women died of cervical cancer in 2018, with more than 85% of these deaths occurring in low- and middle-income countries. The detection of the disease in its later stages has not significantly reduced since 2018 (32.6% of all cases). AIM: The aim of this study was to compare the information contents of conventional and liquid cytology methods in women with verified human papillomavirus of high oncogenic risk. MATERIALS AND METHODS: We retrospectively analyzed 50 outpatient records of women aged 23 to 65 years who underwent colposcopy (cervical biopsy) based on the results of cervical screening. To establish the diagnosis, all patients underwent examination of smears from the cervix and cervical canal using conventional (n = 25) and liquid (n = 25) cytology methods. A molecular genetic study was carried out to detect high-oncogenic human papillomavirus types (16, 18, 31, 33, 35, 45, 51, 56, 58) in scraping of the cervix by real-time polymerase chain reaction. Women in the both study groups also underwent colposcopy with histological examination of the cervical biopsy specimen. The analysis of the obtained data was carried out using methods of parametric and nonparametric statistics. Inclusion criteria included cytological examination, verified human papillomavirus of high oncogenic risk, and colposcopy. Exclusion criteria included pregnancy and acute infectious diseases. RESULTS: According to the results of histological examination, the percentage of coincidence of cytological and histological diagnosis in the group of women who underwent conventional cytological examination was 48%. The total number of discrepancies in this group was 13 (52.0 9.99%). The number of women infected with human papillomavirus in the both study groups was almost the same (18 in the conventional cytology group and 19 in the liquid cytology group). The most common types of human papillomavirus among the examined patients were the 16th type (9 women) and the 18th type (6 women). CONCLUSIONS: To date, cytological research methods have not lost their relevance, the liquid cytology method being a reliable screening test with high specificity, which reduces the number of unsatisfactory preparations for analysis and false negative results. The most informative for women with type 2 or type 3 of transformation zone is the use of the liquid cytology method.

Currently, the demographic situation in modern Russia is not clear. The decline in the nation's reproductive potential is due to negative social trends and the low level of health of women of childbearing age. It is obvious that centralized measures are needed in this situation. A number of authors point to the relevance of the development of psychological assistance to women with infertility, including IVF treatment. However, the system of psychosocial care for women receiving IVF remains underdeveloped. This study is devoted to identifying features of mental States, personal and reactive anxiety in women with a history of unsuccessful IVF attempts. The sociological research was carried out by the method of active questioning of women on special tests. The level of personal and situational anxiety was determined by the Hanin-spielberger tests. The presence of anxiety and depressive reactions at the stage of preparation for treatment should be an indication.

The article describes a clinical case of generalized actinomycosis of the pelvic organs, which occurs very rarely and as a rule in immunocompromised patients. Patient T. came to the women's clinic with complaints of prolonged genital discharge, itching, burning, occasional subfebrileitis. She had a history of prolonged hormonal immunosuppressive therapy. After a thorough examination, the patient was consulted by two oncologists. Preliminary diagnosis: Suspicio cancer coli. Suspicio cancer vaginae. In order to clarify the diagnosis it was decided to perform a multifacial stab biopsy under hospital conditions. The obtained material was sent for an intravital pathological and anatomical examination; no signs of malignancy were found. To prevent complications during surgery, the patient underwent separate diagnostic scraping of the uterine cavity and cervical canal after repeated sanitation of the vagina and additional examination of the patient. Hysteroscopy. Vulval biopsy. Colpocentesis. The final diagnosis was made after the results of culture of microorganisms obtained during the operation on nutrient media. Active growth of actinomycetes was detected in the obtained material. The main clinical diagnosis was pelvic actinomycosis, generalized form. Patient T was discharged in satisfactory condition after antibacterial treatment according to the diagnosis under the observation of a gynecologist at the women's clinic.